Practical Experiences of a Smart Livestock Location Monitoring System leveraging GNSS, LoRaWAN and Cloud Services.

Livestock farming is, in most cases in Europe, unsupervised, thus making it difficult to ensure adequate control of the position of the animals for the improvement of animal welfare. In addition, the geographical areas involved in livestock grazing usually have difficult access with harsh orography and lack of communications infrastructure, thus the need to provide a low-power livestock localization and monitoring system is of paramount importance, which is crucial not for a sustainable agriculture, but also for the protection of native breeds and meats thanks to their controlled supervision. In this context, this work presents an Internet of things (IoT)-based system integrating low-power wide area (LPWA) technology, cloud and virtualization services to provide real-time livestock location monitoring. Taking into account the constraints coming from the environment in terms of energy supply and network connectivity, our proposed system is based on a wearable device equipped with inertial sensors, Global Positioning System (GPS) receiver and LoRaWAN transceiver, which can provide a satisfactory compromise between performance, cost and energy consumption. At first, this article provides the state-of-the-art localization techniques and technologies applied to smart livestock. Then, we proceed to provide the hardware and firmware co-design to achieve very low energy consumption, thus providing a significant positive impact to the battery life. The proposed platform has been evaluated in a pilot test in the Northern part of Italy, evaluating different configurations in terms of sampling period, experimental duration and number of devices. The results are analyzed and discussed for packe delivery ratio, energy consumption, localization accuracy, battery discharge measurement and delay

A Review of Low-end, Middle-end and High-end IoT Devices

Internet of Things (IoT) devices play a crucial role in the overall development of IoT in providing countless applications in various areas. Due to the increasing interest and rapid technological growth of sensor technology, which have certainly revolutionized the way we live today, a need to provide a detailed analysis of the embedded platforms and boards is consequential. This paper presents a comprehensive survey of the recent and most-widely used commercial and research embedded systems and boards in different classification emphasizing their key attributes including processing and memory capabilities, security features, connectivity and communication interfaces, size, cost and appearance, operating system (OS) support, power specifications and battery life and listing some interesting projects for each device. Through this exploration and discussion, readers can have an overall understanding on this area and foster more subsequent studies

Design, Development and Evaluation of an Intelligent Animal Repelling System for Crop Protection Based on Embedded Edge-AI

In recent years, edge computing has become an essential technology for real-time application development by moving processing and storage capabilities close to end devices, thereby reducing latency, improving response time and ensuring secure data exchange. In this work, we focus on a Smart Agriculture application that aims to protect crops from ungulate attacks, and therefore to significantly reduce production losses, through the creation of virtual fences that take advantage of computer vision and ultrasound emission. Starting with an innovative device capable of generating ultrasound to drive away ungulates and thus protect crops from their attack, this work provides a comprehensive description of the design, development and assessment of an intelligent animal repulsion system that allows to detect and recognize the ungulates as well as generate ultrasonic signals tailored to each species of the ungulate. Taking into account the constraints coming from the rural environment in terms of energy supply and network connectivity, the proposed system is based on IoT platforms that provide a satisfactory compromise between performance, cost and energy consumption. More specifically, in this work, we deployed and evaluated various edge computing devices (Raspberry Pi, with or without a neural compute stick, and NVIDIA Jetson Nano) running real-time object detector (YOLO and Tiny-YOLO) with custom-trained models to identify the most suitable animal recognition HW/SW platform to be integrated with the ultrasound generator. Experimental results show the feasibility of the intelligent animal repelling system through the deployment of the animal detectors on power efficient edge computing devices without compromising the mean average precision and also satisfying real-time requirements. In addition, for each HW/SW platform, the experimental study provides a cost/performance analysis, as well as measurements of the average and peak CPU temperature. Best practices are also discussed and lastly, this article discusses how the combined technology used can help farmers and agronomists in their decision making and management process

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)

Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning

Deep Learning in Controlled Environment Agriculture: A Review of Recent Advancements, Challenges and Prospects

Controlled environment agriculture (CEA) is an unconventional production system that is resource efficient, uses less space, and produces higher yields. Deep learning (DL) has recently been introduced in CEA for different applications including crop monitoring, detecting biotic and abiotic stresses, irrigation, microclimate prediction, energy efficient controls, and crop growth prediction. However, no review study assess DL’s state of the art to solve diverse problems in CEA. To fill this gap, we systematically reviewed DL methods applied to CEA. The review framework was established by following a series of inclusion and exclusion criteria. After extensive screening, we reviewed a total of 72 studies to extract the useful information. The key contributions of this article are the following: an overview of DL applications in different CEA facilities, including greenhouse, plant factory, and vertical farm, is presented. We found that majority of the studies are focused on DL applications in greenhouses (82%), with the primary application as yield estimation (31%) and growth monitoring (21%). We also analyzed commonly used DL models, evaluation parameters, and optimizers in CEA production. From the analysis, we found that convolutional neural network (CNN) is the most widely used DL model (79%), Adaptive Moment Estimation (Adam) is the widely used optimizer (53%), and accuracy is the widely used evaluation parameter (21%). Interestingly, all studies focused on DL for the microclimate of CEA used RMSE as a model evaluation parameter. In the end, we also discussed the current challenges and future research directions in this domain

Epistemic groundings for the role of literacy in sustainable development at local governance level

This paper examines the significance of our understanding of the concept of literacy within the context of its role in development at local governance level. It argues that there are different understandings of literacy which requires us to make a choice in terms of our epistemic preferences. Such preferences are seen to be informed by our allegiance to conflicting paradigms in the contexts of sustainable development and education, as the choice we make within the framework of one conflicting paradigmatic options will necessarily become instrumental in our choices within other conflicting paradigms. It concludes that making these choices is essential for those interested in development at local governance level if a clear vision of the what and how of development are to be properly articulated and evaluated

A Review of Low-End, Middle-End, and High-End Iot Devices

Internet of Things (IoT) devices play a crucial role in the overall development of IoT in providing countless applications in various areas. Due to the increasing interest and rapid technological growth of sensor technology, which have certainly revolutionized the way we live today, a need to provide a detailed analysis of the embedded platforms and boards is consequential. This paper presents a comprehensive survey of the recent and most-widely used commercial and research embedded systems and boards in different classification emphasizing their key attributes including processing and memory capabilities, security features, connectivity and communication interfaces, size, cost and appearance, operating system (OS) support, power specifications and battery life and listing some interesting projects for each device. Through this exploration and discussion, readers can have an overall understanding on this area and foster more subsequent studies

Moving beyond neurons:the role of cell type-specific gene regulation in Parkinson’s disease heritability

Abstract Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types